Changqi Zhu, PhD

Changqi Zhu, PhD

Professor
Biological Sciences
Phone: (231) 591-3196
Email: [email protected]

Education

• PhD, University of Karlruhe/Karlsruhe Institute of Technology, Molecular Biology and Animal Developmental Biology
• MS, Master of Agriculture, Northwest Agricultural University, Plant Genetics
• BS, Shaanxi Normal University, Biology

Graduate/Post-Graduate Training

• Postdoctoral Research Associate, University of Minnesota, Minneapolis, MN, United States
• Postdoctoral Research Associate, St. Jude Children's Research Hospital, Memphis, TN, United States

Biography

Dr. Changqi C. Zhu teaches Current Topics in Biology, Developmental Biology, and General Biology courses. His teaching is to inspire and empower students to explore their learning potentials to achieve the best learning outcomes as they can. In addition to teaching, he finds time actively mentoring a small group of students from the Department of Biological Sciences to do research in his research laboratory yearly. Over the last several years, by collaborating with Prof. Michael B. O'Connor lab, Dr. Zhu and his students have discovered two Activin-type ligands Dawdle and Myoglianin as important anti-aging regulators, and published their research findings in Biology Open in April 2018. Besides teaching and research, he also actively serves on different committees at the department, college, and university levels.

Publications and Intellectual Contributions

• Journal Article
  Bierlein, M., Charles, J., Polisuk-Balfour, T., Bretscher, H., Rice, M., Zvonar, J., Pohl, D., Winslow, L., Wasie, B., Deurloo, S., Van Wert, J., Williams, B. M., Ankney, G., Harmon, Z., Dann, E., Azuz, A., Guzman-Vargas, A., Kuhns, E., Neufeld, T. P., O'Connor, M. B., Amissah, F., Zhu, C. (2023). "Autophagy impairment and lifespan reduction caused by Atg1 RNAi or Atg18 RNAi expression in adult fruit flies (Drosophila melanogaster)." Genetics. 225 (2). pp. 1-17. Oxford, England: Oxford University Press. https://academic.oup.com/genetics/article-abstract/225/2/iyad154/7245786?redirectedFrom=fulltext
• Editorial
  Patil, S., Hu, L., Zhu, C., Xian, C. J., Qian, A. (2022). "Editorial: Development, metabolism, senescence and mechanotransduction of bone." Frontiers in cell and developmental biology. 10 p. 1103581.
• Journal Article
  Langerak, S., Kim, M. J., Lamberg, H., Godinez, M., Main, M., Winslow, L., O'Connor, M. B., Zhu, C. (2018). "The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle." Biology open. 7 (4). http://bio.biologists.org/content/biolopen/7/4/bio029454.full.pdf
• Journal Article
  Song, W., Cheng, D., Hong, S., Sappe, B., Hu, Y., Wei, N., Zhu, C., O'Connor, M. B., Pissios, P., Perrimon, N. (2017). "Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control." Cell metabolism. 25 (2). pp. 386-399.
• Journal Article
  Zhu, C., Bornemann, D. J., Zhitomirsky, D., Miller, E. L., O'Connor, M. B., Simon, J. A. (2008). "Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis." PLoS genetics. 4 (2). p. e1000009.
• Journal Article
  Zhu, C., Boone, J. Q., Jensen, P. A., Hanna, S., Podemski, L., Locke, J., Doe, C. Q., O'Connor, M. B. (2008). "Drosophila Activin- and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain." Development (Cambridge, England) 135 (3). pp. 513-21.
• Journal Article
  Lagutin, O. V., Zhu, C., Kobayashi, D., Topczewski, J., Shimamura, K., Puelles, L., Russell, H. R., McKinnon, P. J., Solnica-Krezel, L., Oliver, G. (2003). "Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development." Genes & development. 17 (3). pp. 368-79.
• Journal Article
  Zhu, C., Dyer, M. A., Uchikawa, M., Kondoh, H., Lagutin, O. V., Oliver, G. (2002). "Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors." Development (Cambridge, England) 129 (12). pp. 2835-49.
• Journal Article
  Lagutin, O., Zhu, C., Furuta, Y., Rowitch, D. H., McMahon, A. P., Oliver, G. (2001). "Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos." Developmental dynamics : an official publication of the American Association of Anatomists. 221 (3). pp. 342-9.
• Journal Article
  Zhu, C., Yamada, G., Blum, M. (1999). "Retinoic acid teratogenicity: the role of goosecoid and BMP-4." Cellular and molecular biology (Noisy-le-Grand, France) 45 (5). pp. 617-29.

Presentations

• Poster
  Zhu, C. (Author & Presenter), Society for Developmental Biology 82nd Annual Meeting, "Autophagy impairment and lifespan reduction caused by Atg1 RNAi or Atg18 RNAi expression in adult fruit flies (Drosophila melanogaster)," Society for Developmental Biology, Chicago, Illinois, USA, (July 20, 2023).
• Oral Presentation
  Zhu, C. (Author & Presenter), Invited Seminar Talk, "Knockdown of Atg1 or Atg18 in adult adipocytes impairs lipophagy and reduces the lifespan of fruit flies (Drosophila melanogaster)," Department of Biomedical Sciences, Grand Valley State University, Allendale, Michigan, USA, (January 27, 2023).
• Webinar
  Zhu, C. (Author & Presenter), Invited Seminar Talk, "Tissue-specific requirement of the key autophagy genes in adult fruit fly lifespan regulation," Dr. Osamu Shimmi Lab of Helsinki University, Finland, Big Rapids, Michigan, USA, (October 27, 2022).
• Poster
  Zhu, C. (Author & Presenter), Gordon Research Conference-Systems Aging, "The role of the key autophagy genes in fruit fly lifespan regulation," Gordon Research Conference, Newry, Maine, USA, (May 29, 2022).
• Oral Presentation
  Zhu, C. (Author & Presenter), Invited seminar talk, "Autophagy Genes in Adult Fruit Fly Lifespan Regulation," Northwestern Polytechnical University, Xi'an, China, (June 19, 2019).
• Oral Presentation
  Zhu, C. (Author & Presenter), Invited seminar talk, "Fruit fly Activin signaling in adult lifespan regulation," Shangluo College, Shangluo, Shaanxi Province, China, (July 25, 2018).
• Poster
  Zhu, C. (Author & Presenter), 59th Annual Drosophila Research Conference, "The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle," Genetics Society of America, Philadelphia, Pennsylvania, (April 11, 2018).