Eric Nybo, PhD

Eric Nybo, PhD

Associate Professor of Medicinal Chemistry
Pharmaceutical Science
Phone: (231) 591-2236
Email: [email protected]

Education

• PhD, University of Kentucky, College of Pharmacy, Pharmaceutical Sciences, Natural Products Biosynthesis
• BA, Transylvania University, Biology and Classics

Graduate/Post-Graduate Training

• Fellowship, Postdoctoral Fellowship, University of Kentucky College of Pharmacy, Lexington, KY, United States

Biography

Dr. Nybo grew up in Knoxville, TN until he left for Lexington, KY where he completed his undergraduate and graduate studies. He graduated with a B.A. in Biology and Classics from Transylvania University in 2006. He went onto complete his Ph.D. in Pharmaceutical Sciences from the University of Kentucky in 2011.

He conducted a postdoctoral fellowship in the University of Kentucky Department of Plant and Soil Sciences from 2011-2014 in microbial biofuels research. In 2013, Dr. Nybo was invited back to Transylvania University as a Visiting Assistant Professor of General Chemistry.

Dr. Nybo joined the faculty of the College of Pharmacy, Department of Pharmaceutical Sciences in July 2014.

Publications and Intellectual Contributions

• Journal Article
  Tirkkonen, H., Brown, K. V., Niemczura, M., Faudemer, Z., Brown, C., Ponomareva, L., Helmy, Y., Thorson, J. S., Nybo, E., Metsä-Ketelä, M., Shaaban, K. A. (2023). "Engineering BioBricks® for deoxysugar biosynthesis and generation of new tetracenomycins," ACS Omega. Washington, D.C: American Chemical Society. https://pubs.acs.org/doi/full/10.1021/acsomega.3c02460
• Journal Article
  Bayles, C. E., Hale, D. E., Konieczny, A. M., Anderson, V. D., Richardson, C. R., Brown, K. V., Nguyen, J. T., Hecht, J., Schwartz, N., Kharel, M. K., Amissah, F., Dowling, T. C., Nybo, E. (2022). "Upcycling the anthracyclines: new mechanisms of action, toxicology, and pharmacology," Toxicology and Applied Pharmacology. Frisco, Colorado: Elsevier. https://www.sciencedirect.com/science/article/abs/pii/S0041008X22005075
• Journal Article
  Wang, R., Nguyen, J. T., Hecht, J., Schwartz, N., Brown, K. V., Ponomareva, L., Niemczura, M., van Dissel, D., van Wezel, G., Thorson, J. S., Metsä-Ketelä, M., Shaaban, K. M., Nybo, E. (2022). "A BioBricks® metabolic engineering platform for the biosynthesis of anthracyclinones in Streptomyces coelicolor," ACS Synthetic Biology. Washington, D.C: American Chemical Society Publishing. https://pubs.acs.org/doi/full/10.1021/acssynbio.2c00498
• Journal Article
  Nguyen, J. T., Brown, K. V., Riebschleger, K. K., Gorgijevska, N. M., Nybo, E. (2021). "A BioBricks toolbox for metabolic engineering of the tetracenomycin pathway," Biotechnology Journal. Hoboken, New Jersey: Wiley. https://onlinelibrary.wiley.com/doi/10.1002/biot.202100371
• Journal Article
  Ossai, J., Nybo, S. E., Khatabi, B., Kharel, M. K. (2021). "Renewed interests in the discovery of bioactive actinomycetes metabolites driven by emerging technologies," Journal of Applied Microbiology. Hoboken, New Jersey: Wiley. https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/jam.15225
• Journal Article
  Wandi, B. N., Brown, K., Metsa-Ketela, M., Nybo, E. (2020). "Pathway engineering of anthracyclines: Blazing trails in natural product glycodiversification," Journal of Organic Chemistry. The American Chemical Society. https://doi.org/10.1021/acs.joc.0c01863
• Journal Article
  Nybo, E., Kelly (Sahr), M., Young, M., Axford, K. L., Sohn, M., Lyons, M., Klepser, M. E. (2020). "Design of a large scale escape room for first-year pharmacy student orientation," Currents in Pharmacy Teaching and Learning. Amsterdam, Netherlands: Elsevier. https://www.sciencedirect.com/science/article/pii/S1877129720302173
• Journal Article
  Pontefract, B., Ho, H. T., Crain, A., Kharel, M. K., Nybo, E. (2020). "Drugs for Gram-Negative Bugs from 2010 - 2019: A decade in review," Open Forum Infectious Diseases. Oxford, England: Oxford University Press. https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofaa276/5867191
• Blog Article
  Nybo, E., VanLangen, K. M., Bright, D. R. (2020). "Social Distancing: Transitioning integrated pharmacotherapy coursework from face-to-face delivery to distance learning," Pulses. Currents in Pharmacy Teaching and Learning Scholarly Blog. https://cptlpulses.com/2020/04/07/social-distancing-lessons/
• Cited Research
  Brown, K., Nybo, E. (2020). "Next-generation sequencing of pIJ101-based Streptomyces-E. coli shuttle vectors," bioRxiv. https://www.biorxiv.org/content/10.1101/2020.02.26.966358v1

Presentations

• Oral Presentation
  Nybo, E. (Author & Presenter), Ferris State University Honors Program - Lunch and Learn, "Engineering of natural products," Ferris State University, Honors Program Students, Ferris State University, Big Rapids, Main Campus, (October 3, 2023).
• Oral Presentation
  Nybo, E. (Author & Presenter), College of Pharmacy Alumni Advisory Board, "Program Update: Research updates in the Nybo Laboratory," Ferris State University, College of Pharmacy, Dean's Office, Ferris State University, Big Rapids, Main Campus, (September 29, 2023).
• Lecture
  Nybo, E., Visit to University of Turku, FI, "BIOPOLYMER – BIOBricks POLYketide Metabolic Engineering PlatfoRm," University of Turku, FI, Turku, FI, (August 2, 2022).
• Poster
  Schwartz, J. (Author & Presenter), Schwartz, N. (Author), Nybo, E. (Author), 264th National Meeting of the American Chemical Society, "Engineering of diverse post-PKS enzymatic steps in anthracycline biosynthesis," American Chemical Society, Chicago, IL, (August 20, 2022).
• Poster
  Schwartz, N. (Author & Presenter), Schwartz, J. (Author), Nybo, E. (Author), 264th National Meeting of the American Chemical Society, "BioBricks® platform for engineering of diverse anthracyclinone core scaffolds," American Chemical Society, Chicago, IL, (August 20, 2022).
• Oral Presentation
  Nybo, E. (Author & Presenter), Schwartz, N. (Author), Hecht, J. (Author), 264th National Meeting of the American Chemical Society, "BioBricks® polyketide metabolic engineering platform for the refactoring of the doxorubicin pathway," American Chemical Society, Chicago, IL, (August 23, 2022).
• Lecture
  Nybo, E., Visit to Professor Dr. David Sherman's Laboratory at University of Michigan, "Glycodiversification of the tetracenomycins using combinatorial biosynthesis," University of Michigan, Ann Arbor, MI, (September 7, 2022).
• Poster
  Giri, N. (Author), Nybo, E. (Author), zheng, y. (Author), Qamoum, S. (Author), 2022 Celebration of Student Research & Creative Activities Symposium, "HPLC-LCMS method development for determination and quantification of Antiretroviral agents - Tenofovir and Dapivirine," Ferris State University, University Center -Ferris state university, (September 16, 2022).
• Poster
  Birdsall, K. (Author & Presenter), Brako, A. B. (Author), Nybo, E. (Author), Amissah, F. (Author), 2022 Celebration of Student Research & Creative Activities, "Inhibitory Effect of Tetracenomycins on the Growth of Mammalian Cancer Cells," Ferris State University, Big Rapids, Michigan, (September 16, 2022).
• Poster
  Giri, N. (Author), Nybo, S. (Author), Zheng, Y. (Author), Qamoum, S. (Author), West Michigan Regional Undergraduate Science Research Conference, "HPLC-LCMS method development for quantification of antiretroviral agents- Tenofovir and Dapivirine," Van Andel Institute, Grand Rapids, (November 5, 2022).