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Thomas C. Dowling, PharmD, PhD, FCCP

Thomas C. Dowling, PharmD, PhD, FCCP

Thomas C. Dowling, PharmD, PhD, FCCP
Thomas C. Dowling, PharmD, PhD, FCCP

Assistant Dean (Research) and Professor
Director, Office of Research and Sponsored Programs
Dean's Office
Phone: (616) 643-1139
Email: [email protected]

Education

  • PhD, University of Pittsburgh, Pharmaceutical Sciences (1999)
  • PharmD, Ferris State University, Pharmacy (1993)

Graduate/Post-Graduate Training

  • Residency, Pharmacy Practice (PGY-1), University of Maryland Medical System (1994), Baltimore, MD

Biography

Following a 15-year career as a Professor at the University of Maryland, I now have a great opportunity to work with FSU leadership and faculty across the University to promote research and the teacher-scholar model at my beloved alma mater. The underlying premise of the teacher-scholar model is that the best teachers are those that are actively engaged in scholarship and creation of new knowledge to benefit the public. Including our students in research projects further develops their critical thinking, cultivates the growth mindset, and improves student success and retention.

In my current role at FSU, I enjoy helping faculty find their research "niche" or focus areas, identify grants/contract opportunities, help to secure internal resources to support research equipment/software, manage intellectual property (patents, etc), promote the advancement of new knowledge with a goal of disseminating research findings that has a positive impact on our society. This aligns with the vision of our founder, Woodbridge N. Ferris, who embraced innovation and research.

Since 1994, my teaching and research have focused on a discipline of pharmacokinetics - or the study of how fast drugs move through the body including Absorption, Distribution, Metabolism and Excretion (also referred to as "ADME"). Over the course of my career, I have been able to work with some of the top scholars on research in this field. I have taught undergraduate and graduate courses in pharmacokinetics at University of Maryland, University of Pittsburgh and Ferris State. Over the past 20 years, I have received over $4 Million in research funding to develop new drugs and measure kidney function in new ways. Many of these approaches are now used in FDA regulated clinical trials and NIH-funded studies in patients with liver disease, heart failure, and kidney transplant. With colleagues at Baylor University College of Medicine, we are working to develop better ways to monitor kidney function using metabolomics in patients with advanced liver cirrhosis. In collaboration with scientists at the University of Maryland's Institute of Human Virology, we are working to better understand the pharmacokinetics of newly discovered drugs to treat viral infections using a humanized mouse model. Research is also underway with Dr. Andre Bachmann's group at Michigan State University (GR) to optimize dosing regimens for the drug eflornithine (DFMO) that is active against some forms of childhood cancers. I am also working with FSU undergraduate students in the Shimadzu Core Lab to develop new analytical methods using state-of-the LC-MS/MS equipment.

Professional Service:
- FDA Advisory Committee on matters related Pharmaceutical Sciences policy and drug approvals
- ACPE Accreditation Site Team Reviewer (2020 - )

Publications and Intellectual Contributions

  • Journal Article
    Dowling, T. C. (2021). "TEST - NEW PUBLICATION Sept 4, 2021," Journal. Volume (Issue). p. Page numbers.
  • Journal Article
    Schultz, C. R., Swanson, M. A., Dowling, T. C., Bachmann, A. S. (2021). "Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma." Cancer Chemotherapy and Pharmacology. (88(4); 607-617). pp. 607-617.
  • Journal Article
    Chen AMH, Sweeney, M., Sprague, J. E., Dowling, T. C., Durst, S. W., Eberle, M. M., Stolte, S. K., Talbot, J. N. (2020). "Stimulating and sustaining scholarly activity at teaching-intensive institutions." Currents in pharmacy teaching & learning. 13 (3). pp. 228-237.
  • Journal Article
    Mindikoglu, A. L., Coarfa, C., Opekun, A. R., Shah, V. H., Arab, J. P., Lazaridis, K. N., Putluri, N., Ambati, C. R., Robertson, M. J., Devaraj, S., Jalal, P. K., Rana, A., Goss, J. A., Dowling, T. C., Weir, M. R., Seliger, S. L., Raufman, J. P., Bernard, D. W., Vierling, J. M. (2020). "Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis." Future science OA. 6 (2). p. FSO441. https://www.future-science.com/doi/10.2144/fsoa-2019-0124
  • Journal Article
    Stockton, W., Nguyen, T., Zhang, L., Dowling, T. C. (2019). "Etoposide and etoposide phosphate hypersensitivity in children: Incidence, risk factors, and prevention strategies," Journal of Oncology Pharmacy Practice. pp. 1-9. https://doi.org/10.1177/1078155219858390
  • Book Chapter
    Bernknopf, A. C., Dowling, T. C. (2019). "Randomized Controlled Trials (Ch. 4)," Principles of Research Design and Drug Literature Evaluation. (2nd Edition (2019)). New York, NY: McGraw-Hill. https://accesspharmacy.mhmedical.com/book.aspx?bookID=2733
  • Book Chapter
    Dowling, T. C. (2019). "Chapter 8: Drugs and the Body: Basic Biopharmaceutics, Pharmacokinetics and Pharmacodynamics," ASHP Manual for Pharmacy Technicians, 5th Edition (Bachenheimer) (5th Edition). pp. 263-281. Bethesda, MD: ASHP. https://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=657742967
  • Book Chapter
    Nguyen, T., Tran, T., Dowling, T. C. (2019). "Chapter 21. Principles of Drug Therapy in Reduced Kidney Function," Kidney Protection: A Practical Guide to Preserving Renal Function in Acute and Chronic Disease. (1st Edition). New York, NY: Oxford University Press. https://global.oup.com/academic/product/kidney-protection-9780190611668?cc=us&lang=en&#
  • Journal Article
    Mindikoglu, A. L., Opekun, A. R., Mitch, W. E., Magder, L. S., Christenson, R. H., Dowling, T. C., Weir, M. R., Seliger, S. L., Howell, C. D., Raufman, J. P., Rana, A., Goss, J. A., Khaderi, S. A., Vierling, J. M. (2018). "Cystatin C Is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis," Digestive diseases and sciences. 63 (3). pp. 665-675. https://doi.org/10.1007/s10620-017-4897-z
  • Journal Article
    Mindikoglu, A. L., Opekun, A. R., Putluri, N., Devaraj, S., Sheikh-Hamad, D., Vierling, J. M., Goss, J. A., Rana, A., Sood, G. K., Jalal, P. K., Inker, L. A., Mohney, R. P., Tighiouart, H., Christenson, R. H., Dowling, T. C., Weir, M. R., Seliger, S. L., Hutson, W. R., Howell, C. D., Raufman, J. P., Magder, L. S., Coarfa, C. (2018). "Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis," Translational research : the journal of laboratory and clinical medicine. 195 pp. 25-47. https://doi.org/10.1016/j.trsl.2017.12.002

Presentations

  • Webinar
    Dowling, T. C., 2021 AACP Annual Meeting, "Payment for Direct Patient Care - Are We (Still) Giving Away Services for Free," AACP, Virtual, (July 22, 2021).
  • Webinar
    Dowling, T. C., 2021 Spring Seminar, "Pitfalls in Estimating Kidney Function," FSU College of Pharmacy, Virtual, (May 25, 2021).
  • Webcast
    Dowling, T. C., 2021 AMCP Annual Meeting, "Overview of Anemia in CKD: The Potential Role of HIF-PH Inhibitors," Academy of Managed Care Pharmacy, Virtual, (April 15, 2021).
  • Oral Presentation
    Klepser, M. E., Dowling, T. C., Durst, S. W., Damari, D. A., Konieczny, A. M., 2021 FSU HatchEd, "FLITE Pilot Project: Embedded Librarian Arrangement has Taken Off," Ferris State University, Webinar, (February 18, 2021).
  • Oral Presentation
    Dowling, T. C. (Panelist), Stapp, W. (Panelist), Stakley, D. (Co-Chair), Peterson, A. (Co-Chair), Herrington, H. (Panelist), Russo, T. (Panelist), Konieczny, A. M. (Author & Presenter), Buys, A. M. (Panelist), HatchEd, "Pursuing External [email protected]: Matchmaking 101," Ferris State University, Zoom, (February 18, 2021).
  • Poster
    Dowling, T. C., Thomas, A., Gums, J., 2021 ACCP Annual Meeting, "National Trends in Direct Patient Care and Payment Models Among Pharmacy," American College of Clinical Pharmacy, Virtual, (October 20, 2020).
  • Poster
    Cucci, M., Roberts, J., Murphy, C., Gerlach, A., Udy, A., Mangira, C., Dowling, T. C., Mullen, C., 2020 ACCP Spring Virtual Poster Symposium, "Performance of the Cockcroft-Gault equation using different body weights in ICU patients with augmented renal clearance: A preliminary analysis," American College of Clinical Pharmacy, Virtual, (May 27, 2020).
  • Oral Presentation
    Dowling, T. C. (Presenter), 2019 ASHP Midyear Clinical Meeting, "Defining the Role of Pharmacists in the Evolving Treatment Landscape for Anemia in CKD," ASHP, Las Vegas, NV, (December 9, 2019).
  • Poster
    Swanson, M., Szarowicz, C., Dowling, T. C., Pike, S., Shultz, C., Bachmann, A., West Michigan Research Undergraduate Symposium (WMRUGS), "Development of an LCMS Assay to Quantify DFMO in Mouse Plasma," Van Andel Research Institute, Grand Rapids, MI, (November 4, 2019).
  • Poster
    Swanson, M., Szarowicz, C., Dowling, T. C., Pike, S., Shultz, C., Bachmann, A., Society of Toxicology, "Development of an LCMS Assay to Quantify DFMO in Mouse Plasma," Society of Toxicology, Ann Arbor, MI, (October 18, 2019).