Thomas C. Dowling, PharmD, PhD, FCCP

Thomas C. Dowling, PharmD, PhD, FCCP
Thomas C. Dowling, PharmD, PhD, FCCP

Professor and Assistant Dean for Professional Development and Research
Director, Office of Research and Sponsored Programs
Dean's Office
Phone: (616) 643-1139
Email: [email protected]

Education

  • PhD, University of Pittsburgh, Pharmaceutical Sciences (1999)
  • PharmD, Ferris State University, Pharmacy (1993)

Graduate/Post-Graduate Training

  • Residency, Pharmacy Practice (PGY-1), University of Maryland Medical System (1994), Baltimore, MD

Biography

Following a 15-year career as a Professor at the University of Maryland, I now have the opportunity to work with FSU leadership and faculty across the University to promote growth of the teacher-scholar model and give back to my alma mater. The underlying premise of the teacher-scholar model is that the best teachers are those that are actively engaged in scholarship and advancement of new knowledge. Including our students in research projects further develops their critical thinking, cultivates the growth mindset, and improves student success and retention.

In my current role at FSU, I help faculty find their research "niche" or focus areas, identify grants/contract opportunities, help to secure internal resources to support research equipment/software, manage intellectual property (patents, etc), promote the advancement of new knowledge with a goal of disseminating research findings that has a positive impact on our society.

My teaching and research interests are in the discipline of pharmacokinetics - or the study of how fast drugs move through the body including Absorption, Distribution, Metabolism and Excretion (also referred to as "ADME"). Over the course of my career, I have been able to work with some of the top scholars on research in this field. I have taught undergraduate and graduate courses in pharmacokinetics at FSU, University of Maryland and University of Pittsburgh. Over the past 20 years, I have applied pharmacokinetic principles in the medical specialty of nephrology (kidney diseases). I have developed novel approaches to measure kidney function that are used in FDA regulated clinical trials and in NIH-funded studies in patients with liver disease, heart failure, and kidney transplant. With collaborators at Baylor University College of Medicine, we are working to develop better ways to monitor kidney function using metabolomics in patients with advanced liver cirrhosis. In collaboration with scientists at the University of Maryland's Institute of Human Virology, we are working to better understand the pharmacokinetics of newly discovered drugs to treat viral infections using a humanized mouse model. Research is also underway with Dr. Andre Bachmann's group at Michigan State University (GR) to optimize dosing regimens for the drug eflornithine (DFMO) that is active against some forms of childhood cancers. I am also working with FSU undergraduate students in the Shimadzu Core Lab to develop new analytical methods using state-of-the LC-MS/MS equipment.

Professional Service:
- FDA Advisory Committee on matters related Pharmaceutical Sciences policy and drug approvals
- ACPE Accreditation Site Team Reviewer (2020 - )

Publications and Intellectual Contributions

  • Journal Article
    Mindikoglu, A. L., Coarfa, C., Opekun, A. R., Shah, V. H., Arab, J. P., Lazaridis, K. N., Putluri, N., Ambati, C. R., Robertson, M. J., Devaraj, S., Jalal, P. K., Rana, A., Goss, J. A., Dowling, T. C., Weir, M. R., Seliger, S. L., Raufman, J. P., Bernard, D. W., Vierling, J. M. (2020). "Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis." Future science OA. 6 (2). p. FSO441. https://www.future-science.com/doi/10.2144/fsoa-2019-0124
  • Journal Article
    Stockton, W., Nguyen, T., Zhang, L., Dowling, T. C. (2019). "Etoposide and etoposide phosphate hypersensitivity in children: Incidence, risk factors, and prevention strategies," Journal of Oncology Pharmacy Practice. pp. 1-9. https://doi.org/10.1177/1078155219858390
  • Book Chapter
    Bernknopf, A. C., Dowling, T. C. (2019). "Randomized Controlled Trials (Ch. 4)," Principles of Research Design and Drug Literature Evaluation. (2nd Edition (2019)). New York, NY: McGraw-Hill. https://accesspharmacy.mhmedical.com/book.aspx?bookID=2733
  • Book Chapter
    Dowling, T. C. (2019). "Chapter 8: Drugs and the Body: Basic Biopharmaceutics, Pharmacokinetics and Pharmacodynamics," ASHP Manual for Pharmacy Technicians, 5th Edition (Bachenheimer) (5th Edition). pp. 263-281. Bethesda, MD: ASHP. https://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=657742967
  • Book Chapter
    Nguyen, T., Tran, T., Dowling, T. C. (2019). "Chapter 21. Principles of Drug Therapy in Reduced Kidney Function," Kidney Protection: A Practical Guide to Preserving Renal Function in Acute and Chronic Disease. (1st Edition). New York, NY: Oxford University Press. https://global.oup.com/academic/product/kidney-protection-9780190611668?cc=us&lang=en&#
  • Journal Article
    Mindikoglu, A. L., Opekun, A. R., Putluri, N., Devaraj, S., Sheikh-Hamad, D., Vierling, J. M., Goss, J. A., Rana, A., Sood, G. K., Jalal, P. K., Inker, L. A., Mohney, R. P., Tighiouart, H., Christenson, R. H., Dowling, T. C., Weir, M. R., Seliger, S. L., Hutson, W. R., Howell, C. D., Raufman, J. P., Magder, L. S., Coarfa, C. (2018). "Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis," Translational research : the journal of laboratory and clinical medicine. 195 pp. 25-47. https://doi.org/10.1016/j.trsl.2017.12.002
  • Journal Article
    Mindikoglu, A. L., Opekun, A. R., Mitch, W. E., Magder, L. S., Christenson, R. H., Dowling, T. C., Weir, M. R., Seliger, S. L., Howell, C. D., Raufman, J. P., Rana, A., Goss, J. A., Khaderi, S. A., Vierling, J. M. (2018). "Cystatin C Is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis," Digestive diseases and sciences. 63 (3). pp. 665-675. https://doi.org/10.1007/s10620-017-4897-z
  • Book Chapter
    Dowling, T. C. (2017). "Drug Dosing in Kidney Disease and Dialysis," Winter's Basic Clinical Pharmacokinetics (2017) (6th Edition). Philadelphia, PA: Wolters Kluwer. https://www.amazon.com/Winters-Clinical-Pharmacokinetics-Beringer-PharmD/dp/1496346424
  • Journal Article
    Medina-Moreno, S., Dowling, T. C., Zapata, J. C., Le, N. M., Sausville, E., Bryant, J., Redfield, R. R., Heredia, A. (2017). "Targeting of CDK9 with indirubin 3'-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice." PLoS One. 12 (8). p. e0183425. https://doi.org/10.1371/journal.pone.0183425
  • Book Chapter
    Vanloo, D. A., Dowling, T. C. (2017). "Renal Drug Dosing Concepts," In J. E. Murphy (Ed.), Clinical Pharmacokinetics (2017) (6th Edition). Bethesda, MD: ASHP. https://store.ashp.org/Default.aspx?TabID=251&productId=514496146

Presentations

  • Poster
    Swanson, M., Szarowicz, C., Dowling, T. C., Pike, S., Shultz, C., Bachmann, A., West Michigan Research Undergraduate Symposium (WMRUGS), "Development of an LCMS Assay to Quantify DFMO in Mouse Plasma," Van Andel Research Institute, Grand Rapids, MI, (November 4, 2019).
  • Poster
    Swanson, M., Szarowicz, C., Dowling, T. C., Pike, S., Shultz, C., Bachmann, A., Society of Toxicology, "Development of an LCMS Assay to Quantify DFMO in Mouse Plasma," Society of Toxicology, Ann Arbor, MI, (October 18, 2019).
  • Oral Presentation
    Dowling, T. C., 2019 ACCP MeRIT Conference, "Overview of Designing Clinical Trials," American College of Clinical Pharmacy, Lexington, KY, (June 26, 2019).
  • Oral Presentation
    Dowling, T. C., 2019 ACCP MeRIT Conference, "Crafting Great Research Questions, Aims and Objectives," American College of Clinical Pharmacy, Lexington, KY, (June 25, 2019).
  • Oral Presentation
    Dowling, T. C., 2018 ASHP Midyear Clinical Meeting, "Moving Forward with Novel Treatments for Anemia: The Role of HIF-PD Inhibitors," American Society of Health System Pharmacists, Anaheim, CA, (December 4, 2018).
  • Poster
    Stockton, W., Nguyen, T., Zhang, L., Dowling, T. C., 2018 ACCP Global Conference, "Etoposide hypersensitivity in pediatric patients," American College of Clinical Pharmacy, Seattle, Washington, (October 22, 2018).
  • Oral Presentation
    Dowling, T. C., 2018 ACCP MeRIT Conference, "Overview of Designing Clinical Trials," American College of Clinical Pharmacy, Ann Arbor, MI, (June 27, 2018).
  • Oral Presentation
    Dowling, T. C., 2018 ACCP MeRIT Conference, "Crafting Great Research Questions, Aims and Objectives," American College of Clinical Pharmacy, Ann Arbor, MI, (June 25, 2018).
  • Oral Presentation
    Dowling, T. C., Mindikoglu, A., 2017 AASLD Digestive Disease Week, "Robust Metabolomic Signature is Associated with Altered Renal Hemodynamics in Patients with Cirrhosis," AASLD, Chicago, IL, (May 7, 2017).
  • Poster
    Dowling, T. C., Mindikoglu, A., 2017 AASLD Digestive Disease Week, "Serum Creatinine in Female Patients with Cirrhosis Unfairly Bias Liver Transplant Wait List Ranking: Implications for Elimination of Gender Disparities in Access to Orthotopic Liver Transplantation," AASLD, Chicago, IL, (May 7, 2017).